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The Lancet - Sa, 11/11/2017 - 00:00
El-Maouche D, Arlt W, Merke DP. Congenital adrenal hyperplasia. Lancet 2017; 390: 2194–210—In this Seminar (published online first on May 30, 2017), the Contributors section should be added and read “DPM conceived the framework for the Seminar, wrote the Controversial therapies and Future directions sections, contributed to the writing and editing of all sections and figures, and coordinated oversight of the final manuscript. DE-M wrote the first versions of the manuscript, created the figures, and did most of the scientific literature searches.

A ‘magic number’ of people walking across a bridge makes it sway

New Scientist - Ve, 10/11/2017 - 20:00
We thought walking in lock step made bridges sway, like London’s Millennium Bridge when it opened. But it turns out crowd size matters more than rhythm

Human arrivals wiped out the Caribbean’s giant ground sloths

New Scientist - Ve, 10/11/2017 - 18:50
Many giant mammals in the Americas have died out but it has been hard to say whether humans or natural events were responsible. Now, in the Caribbean at least, we know

Watch a monkey floss its teeth with a bird feather

New Scientist - Ve, 10/11/2017 - 17:01
Nicobar long-tailed macaques have learned to use an array of tools, from wrapping prickly food in leaves to avoid getting hurt, to using bird feathers to floss their teeth

Neptune’s other moons were normal until Triton crashed the party

New Scientist - Ve, 10/11/2017 - 15:53
Neptune’s moons are unlike anything in the solar system, thanks to Triton barrelling in and laying waste to the moons that were there before it

Giant coconut crab sneaks up on a sleeping bird and kills it

New Scientist - Ve, 10/11/2017 - 15:30
Coconut crabs were thought to be purely opportunistic scavengers, but these huge arthropods are actually active predators that may dominate their island homes

Medical cannabis vendors must stop making bogus health claims

New Scientist - Ve, 10/11/2017 - 15:24
There are enough real benefits of medical marijuana, so why are people making them up? It’s time to stop overhyping what weed can do

Charge your phone using ambient light and printed solar cells

New Scientist - Ve, 10/11/2017 - 15:21
Printed plastic solar cells should be able to harvest enough energy from indoor light to power your phone within the next few months

Grow fake versions of rare delicacies like sea urchin at home

New Scientist - Ve, 10/11/2017 - 14:51
Japanese meat culturing project goes beyond hamburger to copy problematic delicacies like sea urchin, foie gras - and someday maybe dinosaur

A bizarre supernova keeps exploding over and over again

New Scientist - Ve, 10/11/2017 - 13:00
The weirdest supernova ever seen is a zombie star that keeps collapsing and coming back to life. It’s so strange, it may be a whole new kind of celestial object

Tracking the first interstellar asteroid back to its home star

New Scientist - Gi, 09/11/2017 - 20:41
Last month, astronomers saw the first asteroid from outside our solar system speed by. Now, they're tracing its orbit back to find out where it came from

Power really can corrupt people. Here’s what to do about it

New Scientist - Gi, 09/11/2017 - 17:57
Sleazy scandals show the link between power and bad behaviour. To stop people at the top getting away with it, we need much more scrutiny, says James Bloodworth

Giant star smash-up may have made the biggest neutron star ever

New Scientist - Gi, 09/11/2017 - 17:29
The collision that produced recent gravitational waves may have left behind the biggest neutron star ever seen. But it might have collapsed into a black hole

Five firms aim to power moon-orbiting way station to deep space

New Scientist - Gi, 09/11/2017 - 17:00
Deep Space Gateway is NASA’s planned outpost at the moon for launches to other worlds. The agency has awarded 5 contracts to start working out how to power it

Meet the winners of the biggest ever face-recognition challenge

New Scientist - Gi, 09/11/2017 - 13:45
Everyone from Apple to the security services is scrambling to improve their face-recognition software – just how good is it?

Validity of a minimally invasive autopsy for cause of death determination in maternal deaths in Mozambique: An observational study

PLoS Medicine - Me, 08/11/2017 - 23:00

by Paola Castillo, Juan Carlos Hurtado, Miguel J. Martínez, Dercio Jordao, Lucilia Lovane, Mamudo R. Ismail, Carla Carrilho, Cesaltina Lorenzoni, Fabiola Fernandes, Sibone Mocumbi, Zara Onila Jaze, Flora Mabota, Anelsio Cossa, Inacio Mandomando, Pau Cisteró, Alfredo Mayor, Mireia Navarro, Isaac Casas, Jordi Vila, Maria Maixenchs, Khátia Munguambe, Ariadna Sanz, Llorenç Quintó, Eusebio Macete, Pedro Alonso, Quique Bassat, Jaume Ordi, Clara Menéndez

Background

Despite global health efforts to reduce maternal mortality, rates continue to be unacceptably high in large parts of the world. Feasible, acceptable, and accurate postmortem sampling methods could provide the necessary evidence to improve the understanding of the real causes of maternal mortality, guiding the design of interventions to reduce this burden.

Methods and findings

The validity of a minimally invasive autopsy (MIA) method in determining the cause of death was assessed in an observational study in 57 maternal deaths by comparing the results of the MIA with those of the gold standard (complete diagnostic autopsy [CDA], which includes any available clinical information). Concordance between the MIA and the gold standard diagnostic categories was assessed by the kappa statistic, and the sensitivity, specificity, positive and negative predictive values and their 95% confidence intervals (95% CI) to identify the categories of diagnoses were estimated. The main limitation of the study is that both the MIA and the CDA include some degree of subjective interpretation in the attribution of cause of death.A cause of death was identified in the CDA in 98% (56/57) of cases, with indirect obstetric conditions accounting for 32 (56%) deaths and direct obstetric complications for 24 (42%) deaths. Nonobstetric infectious diseases (22/32, 69%) and obstetric hemorrhage (13/24, 54%) were the most common causes of death among indirect and direct obstetric conditions, respectively. Thirty-six (63%) women were HIV positive, and HIV-related conditions accounted for 16 (28%) of all deaths. Cerebral malaria caused 4 (7%) deaths. The MIA identified a cause of death in 86% of women. The overall concordance of the MIA with the CDA was moderate (kappa = 0.48, 95% CI: 0.31–0.66). Both methods agreed in 68% of the diagnostic categories and the agreement was higher for indirect (91%) than for direct obstetric causes (38%). All HIV infections and cerebral malaria cases were identified in the MIA. The main limitation of the technique is its relatively low performance for identifying obstetric causes of death in the absence of clinical information.

Conclusions

The MIA procedure could be a valuable tool to determine the causes of maternal death, especially for indirect obstetric conditions, most of which are infectious diseases.The information provided by the MIA could help to prioritize interventions to reduce maternal mortality and to monitor progress towards achieving global health targets.

Letting robots kill without human supervision could save lives

New Scientist - Me, 08/11/2017 - 19:00
Calls to ban killer robots ignore the fact that human soldiers can make lethal mistakes. If driverless cars will save lives, perhaps armed machines can as well

Boy with a genetic disease has had almost all his skin replaced

New Scientist - Me, 08/11/2017 - 19:00
Gene therapy has saved the life of a boy with a rare skin-peeling disease. The boy received grafts of sheets of genetically-altered skin grown in the lab

When it comes to climate, Donald Trump is in a club by himself

New Scientist - Me, 08/11/2017 - 18:22
With pariah state Syria now backing the UN pact to curb global warming, the US stands against the other 195 nations of the world. What a disgrace, says Owen Gaffney

Why burying loved ones in unmarked graves could save wildlife

New Scientist - Me, 08/11/2017 - 17:55
If we all abandoned traditional burials and instead were buried in nature reserves, the money raised could help preserve every endangered species on land
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