Riviste scientifiche

[Correspondence] Overestimation of cardiovascular outcome incidence – Authors' reply

The Lancet - Sa, 09/12/2017 - 00:00
We thank Yuanzi Ye and Ricardo Fonseca for their interest in our Article.1 We agree that the cumulative incidence of each outcome is slightly overestimated when the simple technique for calculating Kaplan-Meier curves is used instead of a more sophisticated method accounting for competing risks. However, the effect of overestimation is modest and, because it affects all strata simultaneously, the hazard ratios (HRs) between strata are nearly unchanged.

[Correspondence] Antiplatelet cessation to manage bleeding events in elderly people

The Lancet - Sa, 09/12/2017 - 00:00
In their Article in The Lancet, Linxin Li and colleagues (June 13, p 490)1 postulated that the increased risk of bleeding events with antiplatelet therapy in patients older than 75 years is sufficient to routinely prescribe proton-pump inhibitors (PPIs) in this group. This assumption is based on extrapolation from data showing the efficacy of PPIs in prevention of upper gastrointestinal bleeding in a younger population (mean age 68·4 years).2 What the authors do not consider is the opposite solution: cessation of antiplatelet therapy.

[Correspondence] Antiplatelet cessation to manage bleeding events in elderly people – Authors' reply

The Lancet - Sa, 09/12/2017 - 00:00
We agree with Cody Magnusson that little evidence exists to suggest that long-term use of aspirin in primary prevention of vascular events is effective in people older than 70 years. Indeed, we previously suggested that aspirin might be used for primary prevention of vascular events and cancer in people who are middle-aged,1,2 but should then be gradually withdrawn because of the high risk of bleeding at older ages. We await the results of the ASPREE trial,3 which should provide definitive evidence of the short-term benefits and harms of aspirin use in people older than 70 years.

[Department of Error] Department of Error

The Lancet - Sa, 09/12/2017 - 00:00
Pearson M, Metcalfe C, Jayamanne S, et al. Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial. Lancet 2017; 390: 1863–72—In this Article (published online first on Aug 11, 2017), Martin Wilks (Swiss Centre for Applied Human Toxicology, University of Basel, Switzerland) should have been cited in the Data Monitoring Committee. This correction has been made to the online version as of Dec 7, 2017.

[Review] The primary health-care system in China

The Lancet - Sa, 09/12/2017 - 00:00
China has made remarkable progress in strengthening its primary health-care system. Nevertheless, the system still faces challenges in structural characteristics, incentives and policies, and quality of care, all of which diminish its preparedness to care for a fifth of the world's population, which is ageing and which has a growing prevalence of chronic non-communicable disease. These challenges include inadequate education and qualifications of its workforce, ageing and turnover of village doctors, fragmented health information technology systems, a paucity of digital data on everyday clinical practice, financial subsidies and incentives that do not encourage cost savings and good performance, insurance policies that hamper the efficiency of care delivery, an insufficient quality measurement and improvement system, and poor performance in the control of risk factors (such as hypertension and diabetes).

[Review] China's Silk Road and global health

The Lancet - Sa, 09/12/2017 - 00:00
In 2013, China proposed its Belt and Road Initiative to promote trade, infrastructure, and commercial associations with 65 countries in Asia, Africa, and Europe. This initiative contains important health components. Simultaneously, China launched an unprecedented overseas intervention against Ebola virus in west Africa, dispatching 1200 workers, including Chinese military personnel. The overseas development assistance provided by China has been increasing by 25% annually, reaching US$7 billion in 2013.

Research on HIV cure: Mapping the ethics landscape

PLoS Medicine - Ve, 08/12/2017 - 23:00

by Karine Dubé, Laurie Sylla, Lynda Dee, Jeff Taylor, David Evans, Carl Dean Bruton, Adam Gilberston, Lisa Gralinski, Brandon Brown, Asheley Skinner, Bryan J. Weiner, Sandra B. Greene, Amy Corneli, Adaora A. Adimora, Joseph D. Tucker, Stuart Rennie

In an essay, Karine Dubé and coauthors discuss the ethics of preclinical and clinical studies relevant to achieving an HIV cure.

Light from LIGO’s neutron star smashup just got even brighter

New Scientist - Ve, 08/12/2017 - 22:43
The gravitational wave event from August still has surprises in store. Its light is three times brighter now, which may change how we think of gamma ray bursts

Record-breaking two-tonne fish is the heaviest of its kind

New Scientist - Ve, 08/12/2017 - 19:50
The record books say that the ocean sunfish is the heaviest bony fish alive, but in fact the specimen in question belongs to a different species

What do the new ‘gay genes’ tell us about sexual orientation?

New Scientist - Ve, 08/12/2017 - 18:45
Two gene variants have been found to be more common in gay men. New Scientist looks at what this tells us about the way biology shapes our sexuality

That interstellar asteroid could be a shard of a shredded planet

New Scientist - Ve, 08/12/2017 - 18:03
'Oumuamua, an oddly shaped asteroid from beyond our solar system, recently passed by. It may have formed when a planet was ripped into fragments by its star

Will wildfires finally change Rupert Murdoch’s climate stance?

New Scientist - Ve, 08/12/2017 - 17:01
The media-mogul's Santa Monica vineyard was saved from wildfire destruction, but the world may yet burn thanks to his climate views, says Richard Schiffman

Daughters of older mums are more likely to never have children

New Scientist - Ve, 08/12/2017 - 12:45
An analysis of thousands of women has found that the older your mother was when you were born, the more likely you are to be childless – but we don’t know why

US cyberweapons have been stolen and there’s nothing we can do

New Scientist - Ve, 08/12/2017 - 12:35
Malicious code exploits are the new weapons of war, but can we ever reach international agreement on how they should be used and who gets to control them?

Food delivery robots are teaching themselves how to cross roads

New Scientist - Ve, 08/12/2017 - 11:46
Until now, delivery robots have always needed humans to help them when things get tricky. Now machine learning has helped them work out how to manage without us

Africa’s giraffes are being slaughtered by Joseph Kony’s army

New Scientist - Ve, 08/12/2017 - 06:01
Elephants, giraffes, giant elands and chimpanzees are being decimated by poachers linked to violent militias in a lawless region of central Africa

Bizarre supernova may be powered by hidden disc of dust and gas

New Scientist - Gi, 07/12/2017 - 21:31
A supernova that stayed bright for over three years seemed impossible, but it could be explained if the explosion is running into dense rings of dust and gas

Most distant quasar ever seen is way too big for our universe

New Scientist - Gi, 07/12/2017 - 15:30
A quasar from the early universe could help us understand how the biggest black holes form and when the universe had its last major transformation

A boy is missing the vision bit of his brain but can still see

New Scientist - Gi, 07/12/2017 - 15:12
A seven-year-old boy whose brain doesn’t have a visual processing centre has baffled doctors. Despite missing this brain area, he is still able to see

Robot’s terrible jokes are a new test of machine intelligence

New Scientist - Gi, 07/12/2017 - 14:14
An AI trained to improvise jokes around topics suggested by an audience is testing the ways we perceive and interact with intelligent machines  
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